Epitope mapping of 18K and 14K/2 showed that 18K was similar to vole-adapted scrapie and it was recognized by the antibodies with epitopes from SAF32 (directed to the octarepeat region of PrP) to the C-terminus (Fig 2D and S2 Fig) indicating to be composed of the expected ~80–231 PrPres fragment, similar to the PrPres previously observed in sheep and voles with classical scrapie [19, 20]. The gene discussed is PRNP; the disease is scrapie.