Notably, no matter in nucleus or in cytoplasm, LMO2 generally exhibits complicated functions: as a transcriptional regulator, LMO2 performs dual-direction regulation patterns on different target genes via binding with different DNA-binding factors and binding on different DNA motifs [8–10]; as a cytoplasmic protein, LMO2 binds with a variety of proteins and participate in several cellular processes, either as an oncogene or as a tumor suppressor [14, 16, 27]. The gene discussed is LMO2; the disease is neoplasm.