PIK3CA and endocrine system disorder: The function “Reproductive System Disease” was the most frequent for the DEMs common to BEAS-AKT1-E17K, BEAS-PIK3CA-E545K and BEAS-shPTEN, and was associated with 16 miRNAs, followed by “Cancer” (14 miRNAs), “Gastrointestinal Disease” (12 miRNAs), “Endocrine System Disorders” (10 miRNAs), and “Hepatic System Disease” (8 miRNAs), respectively.