Extensive studies searching for the underlying tumor suppressor gene have failed to identify a universal 8p tumor suppressor but have revealed multiple 8p genes with documented tumor suppressive properties, such as NKX3.1 [21, 22], CSMD1 [23], DLC1 [24], PPP2CB and PPP3CC [25], MSR1 [26], TNFRSF10C and TNFRSF10D [25]. The gene discussed is NKX3-1; the disease is neoplasm.