KLK3 and benign prostatic hyperplasia: Indeed, although prostate-specific antigen (PSA) tests often suffer from lack of specificity in distinguishing benign prostate hyperplasia from prostate cancer, recent studies indicate that N-glycans of PSA found in prostate cancer differ significantly from those seen in benign prostate hyperplasia and therefore could be a potential indicator leading to improved sensitivity in diagnosing prostate cancer [5].