MAPK8 and Alzheimer disease: Using western blot analysis, IHC staining, and RT2 Profile PCR Arrays focused on genes associated with AD risk factors, we have revealed that icariin can effectively modulate the phosphorylation of signaling molecules, ERK, JNK, Tau and AKT to encounter the Hcy-induced damage of cytoskeleton networks and cell injury in the primary cultures of rat cortical neurons.