APC and colorectal carcinoma: Deeper analysis of the mutator class revealed two subclasses—one defined by altered phosphoinositide 3-kinase (PI3K)– protein kinase B (Akt) signaling and highly enriched for MSI/BRAF-mutated CRC samples, the other defined by KRAS mutations, altered Ras and Wnt signaling, and adenomatous polyposis coli (APC) mutations.