IDH1 and central nervous system cancer: Several functional connections suggest that the cell’s metabolic state may play a role in establishing CIMP, including the observation that mitochondrial-acting IDH1 mutations are sufficient to establish CIMP in glioma [50], they are mutually exclusive with TET mutations, and both are tightly associated with CIMP in at least two different cancers [70,71] including glioma and adult myeloid leukemia.