NCAM1 and cancer: In some mammalian cancer paradigms, unpolysialylated NCAM1 might be sufficient and indispensable for a lipid-raft centered signaling program that coordinates the concomitant disassembly of E-cadherin-based adherence junctions and formation of focal adhesions as a prelude to cellular movement (Frame and Inman, 2008; Lehembre et al., 2008).