HTRA1 and age-related macular degeneration: This is also true for AMD-associated HTRA1 variants rs1049331 and rs2293870, previously reported to strongly influence gene transcription (Yang et al. 2006) and more importantly its ability to bind insulin-like growth factor 1 (Jacobo et al. 2013) or to regulate TGFβ signaling (Friedrich et al. 2015).