Among the strongest loci associated with AMD are the complement factor H (CFH) locus on chromosome 1q32 and a region on chromosome 10q26 harboring two genes, namely age-related maculopathy susceptibility 2 (ARMS2) and HtrA serine peptidase 1 (HTRA1) (Jakobsdottir et al. 2005; Rivera et al. 2005). Here, HTRA1 is linked to age-related macular degeneration.