For example, hepatoblastomas, Wilm’s tumors and most neuroblastomas present early in life, and they often express the oncofetal proteins LIN28 or LIN28B at high levels to help maintain the primitive differentiation states of their respective anlagen (Diskin et al., 2012; Molenaar et al., 2012; Nguyen et al., 2014; Urbach et al., 2014). Here, LIN28B is linked to Nephroblastoma.