Mutations in FLT3, NPM1, DNMT3A, TET2 and IDH1 are all common in adult AML but rare in infant and early childhood AML (Cancer Genome Atlas Research Network, 2013; Ho et al., 2011; Liang et al., 2013; Zwaan et al., 2003). This evidence concerns the gene NPM1 and acute myeloid leukemia.