Both mono- and bi-allelic RUNX1 loss-of-function mutations co-occur with FLT3ITD in human AML (Schnittger et al., 2011), and Runx1 deletions synergize with Flt3ITD to cause AML in mice (Mead et al., 2013). This evidence concerns the gene RUNX1 and acute myeloid leukemia.