The FLT3 Internal Tandem Duplication (FLT3ITD) is an example of an AML driver mutation that occurs more commonly in adults than in young children (30–40% of adult AML, 5–10% of AML in children <10 years old, <1% of infant AML) (Meshinchi et al., 2006). Here, FLT3 is linked to acute myeloid leukemia.