The effects of RO3280 on the 5637 tumour biomarker (nuclear for Ki‐67) are presented in Figure 5E and F. These results suggest that RO3280 exhibits pronounced in vivo effects against bladder cancer xenografts and is associated with target‐specific pharmacodynamic changes in 5637 xenografts. The gene discussed is MKI67; the disease is urinary bladder carcinoma.