ANXA5 and Other metabolic disease: Herein, we highlighted several genes such as G6PD, ITGB2 and ANXA5 which were sorted out from blood related terms including “hemostasis,” “blood coagulation,” “leukocyte migration” and “hereditary hemolytic anemia.” G6PD deficiency is the most common metabolic disorder of red blood cells, affecting about 35 million people worldwide (Nabavizadeh and Anushiravani, 2007).