Aqueous humor levels [mean (range) pg/ml] of angiogenin, IL-8, and MCP-1 were significantly higher in uveal melanoma than in benign pigmented intraocular tumors [angiogenin: 21962.4 (4978.7–84479.6) pg/ml vs. 7071.6 (0–11589.6) pg/ml, p < 0.05; IL-8: 525.6 (16.0–3428.7) pg/ml vs. 33.3 (0–128.6) pg/ml, p < 0.01; MCP-1: 2416.7 (600.1–7723.0) pg/ml vs. 533.7 (117.3–1712.3) pg/ml, p < 0.001]. Here, ANG is linked to uveal melanoma.