Looking for known genes under the linkage peaks (Supplementary Table 4), we found two variants previously related to heart failure, TTN (rs72648923; P = 5.5 × 10-2, MAF = 1.4 × 10-2) and HSD3B1 (P = 3.9 × 10-2 MAF = 1.1 × 10-2). This evidence concerns the gene HSD3B1 and heart failure.