Cyp2e1 was one of the major cytochrome P450 forms whose expression was strongly inhibited by inflammatory cytokines in humans and rodents (Hakkola et al., 2003), and was critically important in non-alcoholic steatohepatitis development by promoting oxidative/nitrosative stress, protein modifications, inflammation, and insulin resistance (Abdelmegeed et al., 2012). The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatohepatitis.