The decreased adiponectin levels were correlated with chronic inflammation associated with obesity, type 2 diabetes, insulin resistance, and atherosclerosis (Berg et al., 2002; Hotamisligil, 2006; Hotamisligil and Erbay, 2008; Holland et al., 2011; Ouchi et al., 2011). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.