MAPT and early-onset autosomal dominant Alzheimer disease: Aggregation of totally or partially disordered proteins has been repeatedly reported to be associated with many human neurodegenerative diseases, including Huntington's, Creutzfeldt-Jakob's, Parkinson's, as well as Alzheimer's disease, and other neurodegenerative disorders as the so-called tauopathies in the case of tau (Avila, 2006).