Although, in a general way, it has been suggested the transition from soluble monomeric tau protein to the formation of large, insoluble, tau aggregates (Takashima, 2013), more studies are needed to test if tau protein follows a protein phase transition in a similar way to that described for the formation of FUS protein aggregates in amyotrophic lateral sclerosis (Patel et al., 2015). Here, MAPT is linked to amyotrophic lateral sclerosis.