The PI3K/PTEN/AKT/mTOR pathway, which consists of phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog (PTEN), v-akt murine thymoma viral oncogene homolog (AKT), and mammalian target of rapamycin (mTOR), has been implicated in the regulation of angiogenesis and metastasis – both important processes in cancer development and progression3, 4. The gene discussed is PTEN; the disease is cancer.