SerpinE2 (Serpin Peptidase Inhibitor, Clade E, Member 2) is a 44 kDa to 50 kDa glycoprotein that is encoded by the SERPINE2 gene on human chromosome 2q99-q354, which is also known as Protease Nexin-1 (PN-1), Glia-Derived Nexin (GDN), or PI-7 etc. SerpinE2/PN-1 expression is observed in a variety of cell types5, 6, such as fibroblasts, vascular smooth muscle cells7, endothelial cells8, platelet particles9, 10, the tumor cells, and so on. The gene discussed is SERPINE2; the disease is neoplasm.