SERPINE2 and persistent truncus arteriosus: To find out the connection of serpinE2 with cardiac fibrosis, the expression for serpinE2 mRNA were conducted using qRT-PCR and these results showed that the expression of serpinE2 mRNA were obviously increased ~5.54 and ~1.94 fold in TAC mouse plasma and in mouse myocardium, respectively (Fig. 1c).