In the final model by forward factor selection (Table 2), the AFS titer in the sputum (odds ratio [OR]: 2.007, 95% CI: 1.181–3.411), nodular-bronchiectasis radiographic pattern (OR: 8.580, 95% CI: 2.069–35.575), and plasma VEGF/PlGF ratio (OR: 1.372, 95% CI: 1.068–1.761) were independent predictors of NTM-LD. The gene discussed is PGF; the disease is bronchiectasis.