SIX5, CHD2, GATA2, ZEB1, NR4A1 were found to have the highest page ranks in the EGF induced network, whereas, MXI1, NFE2, RXRA-VDR, RXRA-NR1H3, SREBF1 had the highest page-rank in the HGR induced networks, further highlighting the importance of these molecules in proliferation and differentiation of breast cancer cells (Fig. 3I,J). The gene discussed is RXRA; the disease is breast carcinoma.