SIX5, CHD2, GATA2, ZEB1, NR4A1 were found to have the highest page ranks in the EGF induced network, whereas, MXI1, NFE2, RXRA-VDR, RXRA-NR1H3, SREBF1 had the highest page-rank in the HGR induced networks, further highlighting the importance of these molecules in proliferation and differentiation of breast cancer cells (Fig. 3I,J). This evidence concerns the gene SIX5 and breast cancer.