The lead SNPs of the two novel loci identified with AvPC4 were both intronic, in ARL15 and ANP32. The allele associated with increased AvPC4 of the lead SNP (rs4865796) in ARL15 was moderately associated with higher BMI (P value=1.6 × 10−4), increased adiponectin levels (P value=4.2 × 10−6 ADIPOGEN37) and decreased risk of diabetes (P value=1.8 × 10−5, DIAGRAM38). The gene discussed is ADIPOQ; the disease is diabetes mellitus.