RPS6KA5 and obesity due to melanocortin 4 receptor deficiency: The lead SNP of the first novel locus rs7492628, upstream of the genes RPS6KA5 (>20 kb) and C14orf159 (>30 kb), failed to reach genome-wide significance in previous WHRadjBMI GWAS (P value=9.3 × 10−8) and was nominally associated with extreme obesity risk (P value=7.26 × 10−5) 28.