The administration of thiamine prevents from obesity and metabolic disorders in Otsuka Long-Evans Tokushima Fatty rats that resemble human metabolic syndrome and obesity71, while pantothenic acid derivatives were found to exert hypolipidemic effect to hypothalamic obesity mice induced by aurothioglucose, potentially by the mechanisms of insulin resistance reduction and lipolysis in serum and adipose tissue72. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.