PSMB4 and hepatocellular carcinoma: This subset included genes whose expression was not strongly correlated with EMT markers in vivo, YWHAE, LTBR, PSMB4 and TRIP13. Overexpression of YWHAE, a 14-3-3 protein, has been shown to promote EMT and increase invasiveness of hepatocellular carcinoma cell lines [58].