APC and non-small cell lung carcinoma: For instance, CDH13, RASSF1A, and APC are identified as DNA methylation markers at stage I in non-small cell lung cancer (NSCLC), and methylation of these genes in the prompter region are associated with early recurrence [25], while methylation of TFPI2 is mainly discovered in advanced stage (stage III) of NSCLC [26].