In melanoma, it has been demonstrated that up regulation of expression of several chemokine genes such as Ccl2, Ccl3, Ccl4, Ccl5, Cxcl9, and Cxcl10 in the tumor microenvironment correlates with the recruitment of activated effector T cells to the tumor increasing antitumor immunity [35]. Here, CCL2 is linked to neoplasm.