Analysis of cytokines and chemokines mRNA levels in the tumor microenvironment of animals with partial response to chemotherapy showed significant increases in mRNA levels for Ccl3, Ccl4, Ccl5, Cxcl9, Cxcl12, Il2, Il12 and Ifng whereas Cxcr4 and Tgfb gene expression were significantly repressed as compared with tumors from untreated mice (Fig. 8). Here, CXCR4 is linked to neoplasm.