AKT1 and breast carcinoma: At 5% FDR, the IPA analysis exhibited the most significant canonical pathways (Fig. 5 and Additional file 16: Table S10), including “protein citrullination” and “complement activation for the breast cancer aberrated genes”, whereas eight significant canonical pathways were discovered for ovarian cancer such as: “role of lipids/lipid, retinoic acid mediated apoptosis signaling, role of RIG1-like receptors in antiviral innate immunity, activation of IRF by cytosolic pattern recognition receptors, and role of PI3K/AKT signaling in the pathogenesis of influenza”.