The top five Toxicology terms were associated with cardiac necrosis/cell death (nominal p-value = 1.18e-06), cardiac hypertrophy (nominal p-value = 2.4e-04), hypoxia-inducible factor signaling (nominal p-value = 3.2e-03), increases liver steatosis (nominal p-value = 3.3e-03) and, PPARA/RXRA activation (nominal p-value = 5.3e-03) (see Additional file 18). Here, RXRA is linked to cardiac hypertrophy.