The following measures are possibly the ‘Countermeasures or compensatory mechanisms by AD affected neurons’ as last attempts for survival which may be protective for certain time such as Tau, Beta Amyloid, S100 – or can speed up AD in the Alzheimer’s disease microenvironment via C-ABL activation, GSK3, neuro-inflammation. Here, S100B is linked to early-onset autosomal dominant Alzheimer disease.