Cardiovascular (CV) biomarkers play an increasingly important role in the diagnosis of cardiac diseases, including the use of cardiac troponins to diagnose acute myocardial infarction [1] and B-type natriuretic peptide (BNP) and N-terminal (NT)-proBNP to diagnose heart failure (HF) [2]. This evidence concerns the gene NPPB and acute myocardial infarction.