Therefore, while still being undoubtedly important, data on mechanisms involved in the effects of LPS on cultured lymphatic muscle cells [36] represent only one part of its direct effects on MLVs (i.e., not linked to interactions with lymphatic endothelial cells), and cannot represent the complex balance of effects of LPS-induced acute peritoneal inflammation brought about by degranulation of mast cells and the action of numerous substances activated by the NF-κB signaling system outside of MLVs. The gene discussed is NFKB1; the disease is inflammation.