INS and Hypoglycemia: Despite the proven efficacy of these antidiabetic drugs, their nonnegligible adverse effects (hypoglycemia with sulfonylureas [SUs] and insulin; weight gain with insulin, SUs, and thiazolidinediones; gastrointestinal [GI] discomfort with metformin [MET], α-glucosidase inhibitors [AGIs], and glucagon-like peptide-1 [GLP-1] receptor agonists) [4–6] have impacted patient compliance, further impeded treatment effects, and elevated healthcare costs [7–11].