Additionally, acquired PAH (without underlying mutations in BMPR2) has resulted from the ingestion of anorexigenic drugs and plant products (e.g. rape seed oil), and parasitic infections (e.g. schistosomiasis) with pathogenesis thought to include underlying inflammation in pulmonary arterial segments accompanied by local cytokine production [3,6]. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.