As shown in Fig 3A, decreased protein expression of phospho-p85, phospho-AKT, and phospho-STAT3 was observed in esophageal cancer cells after CYT-Rx20 treatment, while the total form of p85, AKT, and STAT3 was not significantly altered by CYT-Rx20. The gene discussed is AKT1; the disease is esophageal cancer.