PKCθ was involved in (−)-EA-induced cell death in the 786-0 renal carcinoma cell line (8) but was barely detectable in other (−)-EA-sensitive cells (A498 renal carcinoma and A637 Ewing's sarcoma-derived cell lines) (6, 7), and its proposed mechanism of action, promoting dependence on glucose while simultaneously starving cells of glucose (8), involves relatively slow gene regulatory events. Here, PRRT2 is linked to renal carcinoma.