SIRT2 inhibition has been shown to have a neuroprotective effect in various Parkinson's disease models (Chen et al., 2015; Godena et al., 2014; Outeiro et al., 2007), which was linked to the axonal transport rescue through an increase in tubulin acetylation (Godena et al., 2014). This evidence concerns the gene SIRT2 and Parkinson disease.