Given the positive correlation of BDNF, TrkB, p-ERK and p-CREB with NTG-induced migraine, which was confirmed by this and other studies (Fischer et al., 2012; Isensee et al., 2014; Zhang et al., 2013), these factors are probably involved in the actions of estrogen contributing to migraine, as described in the Fig. 8. The gene discussed is OPA1; the disease is migraine disorder.