A study using IHC showed distribution of p-CREB within the pain-producing areas of the trigeminal system after capsaicin stimulation on meningeal artery; however, the p-CREB staining was attenuated when pre-treated with specific anti-migraine agents, like sumatriptan and naratriptan (Mitsikostas et al., 2011). Here, CREB1 is linked to migraine disorder.