SP3 and viral infectious disease: The Raet1 promoter becomes unrepressed and constitutively bound Sp3 can recruit transcriptional machinery to transcribe Raet1. To circumvent this induction that would target infected cells for elimination by NK-Cells, MCMV encodes a number of highly efficient evasins that prevent NKG2D from recognizing RAE-1 during viral infection (Figure 8).