Some examples include: (1) A96 was reported to reduce pain-related behaviors in a model of osteoarthritis in rats30; (2) HC administration reduced cold hyperalgesia in rat31; and (3) HC and a TRPV1 antagonist, AMG 9810, could synergistically reduce pain-related behaviors in a pancreatitis model32. This evidence concerns the gene TRPV1 and osteoarthritis.