In addition, PLB1 and SAP4 were expressed at a higher level in the co-infection group than in the single infection groups, indicating that enterohemorrhage Escherichia coli promotes the tissue damaging effects of C. albicans, with the presence of extracellular hydrolytic enzymes following PLB1 and SAP4 upregulation. The gene discussed is PLB1; the disease is coinfection.