We suspect that by all these α7nAChR-mediated JAK2/STAT3 activation effects, the combining use of Ani and Neo reduced the death of crushed skeletal muscle fibers (thus less K+ release from injured muscle), and enhanced K+ uptake by surviving skeletal muscles and eventually led to reduced serum K+, an important factor promoting the mortality of CS. This evidence concerns the gene STAT3 and Cowden syndrome 1.