NPHS1 and preeclampsia: Nephrin is a podocyte-specific transmembrane protein that is predominantly localized at the glomerular slit diaphragm of podocytes1 and can detach from the glomerular podocytes, especially in patients with proteinuric diseases, such as a preeclampsia (PE), and is excreted in the urine2, 3, 4, 5, 6.