KAT2B and Hyperglycemia: These effects are consistent with those observed in hepatocytes (Fig. 8a–c) or in the liver of lean mice (Fig. 8e,f), and they indicate that inhibition of GCN5 phosphorylation at Ser275 suppresses gluconeogenesis and therefore ameliorates hyperglycemia, whereas enhanced phosphorylation of GCN5 at Ser275 promotes gluconeogenesis and exacerbates hyperglycemia, in diabetic animals.