Although there was no difference in the amount of oxidized HSA (chronic hepatitis patients, 1.11 ± 0.18 g/dl; CP-A cirrhosis patients, 1.24 ± 0.19 g/dl; CP-B cirrhosis patients, 1.11 ± 0.33 g/dl; CP-C cirrhosis patients, 1.10 ± 0.22 g/dl) (Fig. 2e), there was a significant decrease in the amount of reduced HSA with the progression of liver disease (chronic hepatitis patients, 2.87 ± 0.32 g/dl; CP-A cirrhosis patients, 2.40 ± 0.43 g/dl; CP-B cirrhosis patients, 1.90 ± 0.29 g/dl; CP-C cirrhosis patients, 1.60 ± 0.36 g/dl) (Fig. 2f). The gene discussed is ALB; the disease is congenital primary aphakia.