A significant increase was also seen for the ratio of oxidized HSA to total HSA when it was analyzed with regard to the Child-Pugh classification (CP-A cirrhosis patients, 34.3 ± 5.1%; CP-B cirrhosis patients, 36.6 ± 8.5%; CP-C cirrhosis patients, 41.3 ± 8.0%) (Fig. 2d). Here, ALB is linked to congenital primary aphakia.