Nonetheless, the role of the NLRP3 inflammasome during ureteral obstruction remains controversial, Pulskens et al. found that Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction before 14 days after UUO surgery, they attribute that to the noncanonical effect of Nlrp3 [37]. Here, NLRP3 is linked to Ureteral obstruction.