Within a few years, the CAR field has progressed from reports of anecdotal responses in patients with non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL) to achieving reproducible outcomes in hundreds of patients with B cell malignancies, most strikingly in B cell acute lymphoblastic leukemia (B-ALL), including patients with chemotherapy-refractory disease.48 Indeed, the antitumor activity of anti-CD19 CAR was first reported in a case of advanced follicular NHL, in which anti-CD19 CAR therapy resulted in dramatic regression. The gene discussed is CD19; the disease is B-cell chronic lymphocytic leukemia.