The expression of angiogenic factors such as CXCL1, CXCL5, and CXCL8 was increased in the peripheral blood mice that overexpressed IL-17, whereas CXCR-2 blocked the angiogenic effects of IL-17, which suggests that IL-17 promoted tumour angiogenesis via CXCR-2. This evidence concerns the gene IL17A and neoplasm.