Multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with high BNP after adjustment for age, male gender, previous cardiovascular disease, hypertension, diabetes mellitus, and eGFR (odds ratio, 1.31; 95% confidence interval, 1.13–1.53; P = 0.0004, Table 2). The gene discussed is NPPB; the disease is diabetes mellitus.