To address this interaction between DEX, TRPM2 and TRPV1, we investigated the protective actions of DEX treatment on apoptosis, oxidative stress levels, Ca2+ entry values as well as involvement of TRPM2 and TRPV1 activations on the values in the DRG and HIPPO neurons in rat with cerebral ischemia. Here, TRPV1 is linked to brain ischemia.