CASP3 and brain ischemia: Figures 5 and 6 show the effects of DEX on cerebral ischemia-induced apoptosis, MTT levels, and caspase 3 and 9 activities through TRPM2 (Figs 5A and 6A) and TRPV1 (Figs 5B and 6B) channel activation in the HIPPO neurons.