DSP and neuropathy: However, apoptosis is not a major feature of DSP, and targeting cell death has not been effective at ameliorating disease in dying-back neuropathies (Sagot et al., 1997; Chiesa et al., 2005; Gould et al., 2006), Instead, the pattern of sensory neuron degeneration in DSP progresses distally to proximally in a “stocking and glove” fashion (Keswani et al., 2002), placing DSP in the category of dying-back neuropathies where degeneration represents an early pathogenic feature that long precedes cell death.