EML4 and lung adenocarcinoma: Translocation of the anaplastic lymphoma kinase (ALK) gene echinoderm microtubule-associated proteinlike 4 (EML4) was shown in 5% of patients with lung adenocarcinoma.1 Crizotinib treatment has been reported to safely lead to a response rate of 60% and median progression-free survival of 8 months.2, 3